DRAFT: Please do not cite or circulate without permission.

Research on prevention, treatment, and education has brought us to the point where very significant improvements in the life trajectories of at-risk young people are possible. [1, 2] Major advances in public health are especially likely if we can translate existing knowledge into effective, multicomponent packages of interventions in high-poverty neighborhoods where psychological, social, and behavioral problems are concentrated. However, new evaluation and research strategies will be needed if the promise ...